Members

Postdoctoral Associates

Gangwei Wang

Gangwei WangI obtained my MSci degree in 2010 from Lanzhou University. I then undertook PhD studies in Prof. Yang Shangdong’s group at the State Key Laboratory of Applied Organic Chemistry, Lanzhou University. During this time, my research focused on the development and mechanism of new metal-catalyzed C-H bond functionalisations to construct C-X bonds (X = C, N, O). In August 2015, I started my first postdoctoral appointment in the Bower group, where I am working on new C-C bond activation methodologies.

Publications:

  • G.-W. Wang and J. F. Bower; Modular access to azepines by directed carbonylative C-C bond activation of aminocyclopropanes. J. Am. Chem. Soc. 2018, 140, 2743-2747.
  • G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504.

Awards, Prizes and Fellowships:

  • Royal Society K. C. Wong Postdoctoral Fellowship, 2015.

Xiaofeng Ma

Xiaofeng MaI obtained my PhD degree in 2012 from Chengdu Institute of Biology, Chinese Academy of Sciences under the supervision of Prof. Shao Huawu. I then moved on to a postdoctoral position in Prof. I. E. Marko’s group in Universite catholique de Louvain, where I designed new inibitors for GABA transporters. I also worked on organic electrochemistry, photochemistry and some other industry projects. In March 2016, I joined the Bower Group, where I am working on new C-N bond forming cascades.

Publications:

  • X. Ma, J. J. Farndon, T. Young, N. Fey and J. F. Bower; A simple and broadly applicable C-N bond forming dearomatization protocol enabled by bifunctional amino-reagents. Angew. Chem. Int. Ed. 2017, 56, 14531-14535.
  • J. J. Farndon, X. Ma and J. F. Bower; Transition metal free C-N bond forming dearomatizations and aryl C-H aminations by in situ release of a hydroxylamine-based aminating agent. J. Am. Chem. Soc. 2017, 139, 14005-14008.
  • I. R. Hazelden, X. Ma, T. Langer and J. F. Bower; Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides. Angew. Chem. 2016, 128, 11364-11368; Angew. Chem. Int. Ed. 2016, 55, 11198-11202.

Javier García Cárceles

I graduated from Universidad Complutense de Madrid in 2012 with an MSci in Organic Chemistry. I then carried out my PhD studies under the supervision of Prof. María Luz López Rogríguez in the Medicinal Chemistry Laboratory (UCM) working on the development of new allosteric modulators of G protein-coupled receptors (GPCRs), where I also took a postdoctoral position in 2017. In January 2018, I moved to the Bower group where I am developing novel methods for C-C bond activation.

Awards, Prizes and Fellowships:

  • Fundación Alfonso Martín Escudero Postdoctoral Fellowship, 2017.

Rajender Nallagonda

My M.Sc. degree (2009) was from Osmania University, Hyderabad. I was then a research scientist at GVK Bio science PVT LTD. My PhD  (2016) was under the supervision of Prof. Prasanta Ghorai at the ‘Indian Institute of Science Education and Research Bhopal’, where I researched transition metal-catalysed C-C, C-N and C-O bond forming reactions. Subsequently, I worked at ‘IIT Bombay’ with Prof. Chandra. M. R. Volla and at the ‘HUJI’ with Dr. Ahmad Masarwa.  In February 2018, I moved to the Bower group where I work on aryl C-H functionalisation.

Awards, Prizes and Fellowships:

  • SERB-India Overseas Postdoctoral Fellowship, 2018.

James Wood

I obtained my BSc from the University of Auckland in 2014, before undertaking a PhD there with Distinguished Professor Margaret Brimble and Dr Daniel Furkert. My research focussed on the synthesis of 2-formylpyrrole natural products using a novel Maillard-type reaction. In June 2018 I joined the Bower  group where I am developing novel methods for naphthoquinone synthesis in collaboration with Prof. Eufrânio da Silva Jr. Outside of the lab I enjoy cricket, Friday beers and hiking.


Postgraduate Students

Ian Hazelden

Ian Hazelden

I graduated from the University of Bristol in 2014 with an MSci in Chemistry. During my final year I worked on developing sugar-functionalised hydrogels for tissue culture under the supervision of Professor Tim Gallagher. My PhD research, which is in collaboration with AstraZeneca, involves the development of palladium catalysed C-N bond formations and their application to natural product synthesis. 

Publications:

  • I. R. Hazelden, R. C. Carmona, T. Langer, P. G. Pringle and J. F. Bower; Pyrrolidines and piperidines by ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates. Angew. Chem. Int. Ed. 2018, 57, In press.
  • N. J. Race, I. R. Hazelden, A. Faulkner and J. F. Bower; Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles. Chem. Sci. 20178, 5248-5260.
  • I. R. Hazelden, X. Ma, T. Langer and J. F. Bower; Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides. Angew. Chem. 2016, 128, 11364-11368; Angew. Chem. Int. Ed. 2016, 55, 11198-11202.

Phillippa Cooper

PhillippaI graduated in 2015 from the University of Nottingham with an MSci in Chemistry with a year in industry. My industrial placement was at Endeavour Speciality Chemicals in the research and development department and my final year research project was with Prof. Simon Woodward, where I worked on the synthesis and derivatization of an eight-membered ring. My PhD is in collaboration with AstraZeneca and is focused on aryl C-H functionalization. In my spare time, I enjoy baking, photography and climbing.

Publications:

  • P. Cooper, G. E. M. Crisenza, L. J. Feron and J. F. Bower; Iridium-catalyzed α-selective arylation of styrenes by dual C-H functionalization. Angew. Chem. Int. Ed. 2018, In press.
  • S. Grélaud, P. Cooper, L. J. Feron and J. F. Bower; Branch-selective and enantioselective iridium-catalyzed alkene hydroarylation via anilide-directed C-H oxidative addition.  J. Am. Chem. Soc. 2018, 140, 9351-9356.

Awards, Prizes and Fellowships:

  • RSC postgraduate speaker at J-NOST-14, Indian Institute of Chemical Technology (IICT), Hyderabad, India, November 28-December 1, 2018.
  • 2017 JSPS Fellowship (3 month placement at Nagoya University with Prof. K. Itami).

Steven Stanton

StevenI graduated from the University of St Andrews in 2015 with an MChem in Chemistry with Medicinal Chemistry. During my degree I spent a year working at RedX Oncology in Liverpool and did a final year project with Professor Nicholas Westwood on a novel lignin valorisation process. In September 2015 I started my PhD, which focuses on Rh-catalysed carbonylative ring-expansions. Aside from chemistry I enjoy most sports, in particular basketball, as well as spending time in the pub with friends.

Publications:

  • G. Fumagalli, S. Stanton and J. F. Bower; Recent methodologies that exploit C-C single bond cleavage of strained ring systems by transition metal complexes. Chem. Rev. 2017, 117, 9404-9432. Invited contribution to the 2017 thematic issue on C-H and C-C functionalisation.
  • N. G. McCreanor, S. Stanton and J. F. Bower; Capture-collapse heterocyclization: 1,3-diazepanes by C-N reductive elimination from rhodacyclopentanones. J. Am. Chem. Soc. 2016, 138, 11465-11468.

Joshua Farndon

Joshua Farndon

I graduated from the University of Birmingham in 2015 with an MSci in Chemistry. My final year project, under the supervision of Dr Paul Davies, focused on gold catalysed cyclisations to generate sulfur containing compounds. I then joined the Bristol Chemical synthesis CDT where I am now conducting my PhD project in the Bower group on the development of metal catalysed dearomatisation reactions. Outside of the lab I enjoy football and badminton.

Publications:

  • X. Ma, J. J. Farndon, T. Young, N. Fey and J. F. Bower; A simple and broadly applicable C-N bond forming dearomatization protocol enabled by bifunctional amino-reagents. Angew. Chem. Int. Ed. 2017, 56, 14531-14535.
  • J. J. Farndon, X. Ma and J. F. Bower; Transition metal free C-N bond forming dearomatizations and aryl C-H aminations by in situ release of a hydroxylamine-based aminating agent. J. Am. Chem. Soc. 2017, 139, 14005-14008.

Olivia Boyd

I am originally from Northern Ireland and graduated with an MSci in Chemistry from Imperial College in 2014, where I carried out my research project with Professor Ed Tate. I then worked as a Graduate Scientist for AstraZeneca in Gothenburg, Sweden. I moved to Bristol in September 2016 to start my PhD, which is in collaboration with GSK and will focus on further development of the group’s work on C-C bond activation. Outside of chemistry, I enjoy running, dancing and relaxing with friends.

Awards, Prizes and Fellowships:

  • Runner-up at the second year “Syngenta Poster Competition”, April 30, 2018.

Andrew Dalling

I graduated in 2016 with an MSci in Chemistry from the University of Birmingham. My final year project was undertaken with Dr John Fossey, where I worked on the kinetic resolution of chiral azides and alkynes. I then moved to Bristol in September 2016 to start my PhD, which involves the development and application of rhodium-catalysed C-C bond activation triggered methodologies. In my spare time I enjoy playing football, badminton and the piano.

Publications:

  • A. G. Dalling, T. Yamauchi, N. G. McCreanor, L. Cox and J. F. Bower; Carbonylative C-C bond activation of electron-poor cyclopropanes: rhodium-catalyzed (3+1+2) cycloadditions of cyclopropylamides. Angew. Chem. Int. Ed. 2018, In press.
  • A. G. Dalling and J. F. Bower; Synthesis of nitrogen heterocycles via directed carbonylative C-C bond activation of cyclopropanes. CHIMIA, 2018, In press.

Olga Sokolova

I graduated  from the Higher Chemical College of the Russian Academy of Sciences in 2016, where I researched electrochemical and multicomponent reactions with Prof. Mikhail Elinson at the Zelinsky Institute of Organic Chemistry (2011-16). My first year project was with Dr. Vladimir Burlakov (Nesmeyanov Institute of Organoelement Compounds) and I have also undertaken summer placements in the Bower group and with Prof. Antonio Echavarren (ICIQ). In my spare time, I like drawing, playing billiards and spending time with friends.

Publications:

  • G. E. M. Crisenza, O. O. Sokolova and J. F. Bower; Branch selective alkene hydroarylation via cooperative destabilization: iridium-catalyzed ortho-alkylation of acetanilides. Angew. Chem. 2015, 127, 15079-15083; Angew. Chem. Int. Ed. 2015, 54, 14866-14870. 

Lauren O’Neil

I graduated from the University of Nottingham in 2016 with an MSci in Chemistry. My industrial placement was at Sygnature Discovery and my final year project was with Dr James Dowden, where I investigated enantioselective organocatalytic conjugate additions. I then joined the Bristol Chemical Synthesis CDT and my PhD research is on the total synthesis of complex alkaloids using aza-Heck cyclizations and cascades. In my spare time I play the piano, trumpet and oboe, and enjoy swimming.

Ben Jones

I graduated in 2017 from Heriot-Watt University with an MChem in Chemistry with a year in industry. My industrial placement was at F. Hoffman La-Roche in Basel working in the small molecule research and early development department.  My final year research project was with Prof. Ai-Lan Lee, where I worked on dual gold and photoredox catalysed C-H activation of arenes for intramolecular aryl-aryl cross-couplings. My PhD concerns development of Pd-catalysed aza-Heck cyclisations and cascades.

Madelene Waldron

I graduated in 2017 from the University of Nottingham with an MSci in Chemistry, during which I did a placement at RedX Oncology in Liverpool. My final year project was with Mr Tom McInally, working on the synthesis of biologically active compounds in collaboration with GSK. For my PhD, I am working on the development of new catalyst systems for the activation of C-C bonds. In my spare time, I enjoy playing the violin, creative writing, and playing quidditch.


Co-Supervised Postgraduate Students

Matthew Harper

Matt Harper

I graduated from the University of Bristol in 2013 with a BSc in Chemistry, investigating boron chemistry with Professor Guy Lloyd-Jones for my final year project. I then stayed at Bristol for an MSc by research, working with Dr. Carmen Galan on alpha-selective organocatalytic glycosylations. I am now working on oxidative gold catalysis under the supervision of Dr. Chris Russell and Dr. John Bower, in collaboration with Syngenta. In my spare time, I enjoy cycling, photography and cooking.

Publications:

  • M. J. Harper, C. J. Arthur, J. Crosby, E. J. Emmett, R. L. Falconer, A. J. Fensham-Smith, P. J. Gates, T. Leman, J. E. McGrady, J. F. Bower and C. A. Russell; Oxidative addition, transmetallation and reductive elimination at a 2,2′-bipyridyl ligated gold center. J. Am. Chem. Soc. 2018, 140, In press.
  • M. J. Harper, E. J. Emmett, J. F. Bower and C. A. Russell; Oxidative 1,2-difunctionalization of ethylene via gold-catalyzed oxyarylation. J. Am. Chem. Soc. 2017, 139, 12386-12389.

Awards, Prizes and Fellowships:

  • Best “molecular chemistry” seminar prize at the Inorganic and Materials Postgraduate Symposium, School of Chemistry, University of Bristol, June 25, 2018.
  • Poster prize at the Syngenta Collaborative Research Conference, September 7-8, 2017.
  • Poster prize at the European Chemical Sciences Division of Organometallic Chemistry Conference (EuCOMC), Amsterdam, Netherlands, July 9-13, 2017.

Jamie Cadge

I graduated from the University of Nottingham in 2016 with an MSci degree. After completing summer placements with Dr J. Dowden and at GSK, my final year project was with Dr L. Ball, developing methodology for aromatic fluorinations. I then moved to Bristol to join the Chemical Synthesis CDT, where I am working on the development of Au-catalysed C-X bond formations under the supervision of Dr Chris Russell, Dr John Bower and Prof. Didier Bourissou (University of Toulouse). In my spare time I enjoy watching films, live music and playing the piano.

Awards, Prizes and Fellowships:

  • Poster prize at the Oxford Synthesis Summer Conference, Oxford, June 25-26, 2018.

Undergraduate and Visiting Students

 

 

 

 

Jacob Burley

Rachael Ambler

 

 

 

 

Lewis Caiger

 

 

 

 

Aidan McFord