Former Members

Postgraduate Students

Olga Sokolova

I graduated  from the Higher Chemical College of the Russian Academy of Sciences in 2016, where I researched electrochemical and multicomponent reactions with Prof. Mikhail Elinson at the Zelinsky Institute of Organic Chemistry (2011-16). My first year project was with Dr. Vladimir Burlakov (Nesmeyanov Institute of Organoelement Compounds) and I have also undertaken summer placements in the Bower group and with Prof. Antonio Echavarren (ICIQ). In my spare time, I like drawing, playing billiards and spending time with friends.

Publications:

  • O. O. Sokolova and J. F. Bower; Selective carbon-carbon bond cleavage of cyclopropylamine derivatives. Chem. Rev. 2021, 121, 80-109. Invited contribution to the 2021 thematic issue on “Carbon-Carbon Bond Cleavage in Stereoselective Synthesis.”
  • G.-W. Wang, O. O. Sokolova, T. A. Young, E. M. S. Christodoulou, C. P. Butts and J. F. Bower; Carbonylative C-C bond activation of aminocyclopropanes using a temporary directing group strategy. J. Am. Chem. Soc. 2020, 142, 19006-19011.
  • O. Boyd, G.-W. Wang, O. O. Sokolova, A. D. J. Calow, S. M. Bertrand and J. F. Bower; Modular access to eight-membered N-heterocycles by directed carbonylative C-C bond activation of aminocyclopropanes. Angew. Chem. Int. Ed. 2019, 58, 18844-18848.
  • G. E. M. Crisenza, O. O. Sokolova and J. F. Bower; Branch selective alkene hydroarylation via cooperative destabilization: iridium-catalyzed ortho-alkylation of acetanilides. Angew. Chem. 2015, 127, 15079-15083; Angew. Chem. Int. Ed. 2015, 54, 14866-14870. 

Destination:

Postdoctoral associate with Professor Ryan Gilmour, University of Münster, Germany.

Olivia Boyd

I am originally from Northern Ireland and graduated with an MSci in Chemistry from Imperial College in 2014, where I carried out my research project with Professor Ed Tate. I then worked as a Graduate Scientist for AstraZeneca in Gothenburg, Sweden. I moved to Bristol in September 2016 to start my PhD, which is in collaboration with GSK and will focus on further development of the group’s work on C-C bond activation. Outside of chemistry, I enjoy running, dancing and relaxing with friends.

Publications:

  • G.-W. Wang, O. Boyd, T. A. Young, S. M. Bertrand and J. F. Bower; Rhodacyclopentanones as linchpins for the atom economical assembly of diverse polyheterocycles. J. Am. Chem. Soc. 2020, 142, 1740-1745.
  • O. Boyd, G.-W. Wang, O. O. Sokolova, A. D. J. Calow, S. M. Bertrand and J. F. Bower; Modular access to eight-membered N-heterocycles by directed carbonylative C-C bond activation of aminocyclopropanes. Angew. Chem. Int. Ed. 2019, 58, 18844-18848.

Awards, Prizes and Fellowships:

  • Runner-up at the final year Organic and Biological Chemistry PhD Symposium, June 7, 2019.
  • Runner-up at the second year “Syngenta Poster Competition”, April 30, 2018.

Destination:

Medicinal Scientist at Merck Sharp and Dohme, Crick Institute, London

Andrew Dalling

I graduated in 2016 with an MSci in Chemistry from the University of Birmingham. My final year project was undertaken with Dr John Fossey, where I worked on the kinetic resolution of chiral azides and alkynes. I then moved to Bristol in September 2016 to start my PhD, which involves the development and application of rhodium-catalysed C-C bond activation triggered methodologies. In my spare time I enjoy playing football, badminton and the piano.

Publications:

  • T. P. Aldhous, R. W. M. Chung, A. G. Dalling and J. F. Bower; Enantioselective intermolecular Murai-type alkene hydroarylation reactions. Synthesis 2021In press.
  • A. G. Dalling, T. Yamauchi, N. G. McCreanor, L. Cox and J. F. Bower; Carbonylative C-C bond activation of electron-poor cyclopropanes: rhodium-catalyzed (3+1+2) cycloadditions of cyclopropylamides. Angew. Chem. Int. Ed. 2019, 58, 221-225.
  • A. G. Dalling and J. F. Bower; Synthesis of nitrogen heterocycles via directed carbonylative C-C bond activation of cyclopropanes. Chimia 2018, 72, 595-600.

Awards, Prizes and Fellowships:

  • Syngenta Scholarship finalist, 2020.
  • RSC postgraduate speaker at J-NOST-15, University of Delhi, India, October 18-21, 2019.

Destination:

Postdoctoral associate with Professor Alois Fürstner, Max Planck Institute, Mülheim, Germany.

Joshua Farndon

Joshua Farndon

I graduated from the University of Birmingham in 2015 with an MSci in Chemistry. My final year project, under the supervision of Dr Paul Davies, focused on gold catalysed cyclisations to generate sulfur containing compounds. I then joined the Bristol Chemical synthesis CDT where I am now conducting my PhD project in the Bower group on the development of metal catalysed dearomatisation reactions. Outside of the lab I enjoy football and badminton.

Publications:

  • C. Jing, J. J. Farndon and J. F. Bower; Dearomatizing amination reactions. Chem. Rec. 2021, In press.
  • J. J. Farndon, T. A. Young and J. F. Bower; Stereospecific alkene aziridination using a bifunctional amino-reagent: an aza-Prilezhaev reaction. J. Am. Chem. Soc. 2018140, 17846-17850.
  • X. Ma, J. J. Farndon, T. Young, N. Fey and J. F. Bower; A simple and broadly applicable C-N bond forming dearomatization protocol enabled by bifunctional amino-reagents. Angew. Chem. Int. Ed. 2017, 56, 14531-14535.
  • J. J. Farndon, X. Ma and J. F. Bower; Transition metal free C-N bond forming dearomatizations and aryl C-H aminations by in situ release of a hydroxylamine-based aminating agent. J. Am. Chem. Soc. 2017, 139, 14005-14008.

Destination:

Scientist at Sygnature Discovery, Nottingham, Nottinghamshire, UK.

Phillippa Cooper

PhillippaI graduated in 2015 from the University of Nottingham with an MSci in Chemistry with a year in industry. My industrial placement was at Endeavour Speciality Chemicals in the research and development department and my final year research project was with Prof. Simon Woodward, where I worked on the synthesis and derivatization of an eight-membered ring. My PhD is in collaboration with AstraZeneca and is focused on aryl C-H functionalization. In my spare time, I enjoy baking, photography and climbing.

Publications:

  • P. Cooper, G. E. M. Crisenza, L. J. Feron and J. F. Bower; Iridium-catalyzed α-selective arylation of styrenes by dual C-H functionalization. Angew. Chem. Int. Ed. 2018, 57, 14198-14202.
  • S. Grélaud, P. Cooper, L. J. Feron and J. F. Bower; Branch-selective and enantioselective iridium-catalyzed alkene hydroarylation via anilide-directed C-H oxidative addition.  J. Am. Chem. Soc. 2018, 140, 9351-9356.

Awards, Prizes and Fellowships:

  • Lindemann Trust Fellowship, 2019.
  • RSC postgraduate speaker at J-NOST-14, Indian Institute of Chemical Technology (IICT), Hyderabad, India, November 28-December 1, 2018.
  • Syngenta Scholarship finalist, 2018.
  • 2017 JSPS Fellowship (3 month placement at Nagoya University with Prof. K. Itami).

Destination:

Postdoctoral associate with Professor Keary Engle, Scripps Research, USA.

Steven Stanton

StevenI graduated from the University of St Andrews in 2015 with an MChem in Chemistry with Medicinal Chemistry. During my degree I spent a year working at RedX Oncology in Liverpool and did a final year project with Professor Nicholas Westwood on a novel lignin valorisation process. In September 2015 I started my PhD, which focuses on Rh-catalysed carbonylative ring-expansions. Aside from chemistry I enjoy most sports, in particular basketball, as well as spending time in the pub with friends.

Publications:

  • G. Fumagalli, S. Stanton and J. F. Bower; Recent methodologies that exploit C-C single bond cleavage of strained ring systems by transition metal complexes. Chem. Rev. 2017, 117, 9404-9432. Invited contribution to the 2017 thematic issue on C-H and C-C functionalisation.
  • N. G. McCreanor, S. Stanton and J. F. Bower; Capture-collapse heterocyclization: 1,3-diazepanes by C-N reductive elimination from rhodacyclopentanones. J. Am. Chem. Soc. 2016, 138, 11465-11468.

Destination:

Postdoctoral associate with Professor Paul Wender, Stanford University, USA.

Ian Hazelden

Ian Hazelden

I graduated from the University of Bristol in 2014 with an MSci in Chemistry. During my final year I worked on developing sugar-functionalised hydrogels for tissue culture under the supervision of Professor Tim Gallagher. My PhD research, which is in collaboration with AstraZeneca, involves the development of palladium catalysed C-N bond formations and their application to natural product synthesis. 

Publications:

  • B. T. Jones, J. García-Cárceles, L. Caiger, I. R. Hazelden, R. J. Lewis, T. Langer and J. F. Bower; Complex polyheterocycles and the stereochemical reassignment of pileamartine A via aza-Heck triggered aryl C-H functionalization cascades. J. Am. Chem. Soc. 2021, In press.
  • X. Ma, I. R. Hazelden, T. Langer, R. H. Munday and J. F. Bower; Enantioselective aza-Heck cyclizations of N-(tosyloxy)carbamates: synthesis of pyrrolidines and piperidines. J. Am. Chem. Soc. 2019, 141, 3356-3360.
  • I. R. Hazelden, R. C. Carmona, T. Langer, P. G. Pringle and J. F. Bower; Pyrrolidines and piperidines by ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates. Angew. Chem. Int. Ed. 2018, 57, 5124-5128.
  • N. J. Race, I. R. Hazelden, A. Faulkner and J. F. Bower; Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles. Chem. Sci. 20178, 5248-5260.
  • I. R. Hazelden, X. Ma, T. Langer and J. F. Bower; Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides. Angew. Chem. 2016, 128, 11364-11368; Angew. Chem. Int. Ed. 2016, 55, 11198-11202.

Destination:

Technology and Innovation Graduate Scheme, Liberty Global, Amsterdam, Netherlands.

Craig Buxton

Craig Buxton

I graduated from the University of Bristol in 2012 with an MSci in Chemistry. I completed a final year project on palladium catalysed cyclisations of oxime esters under the supervision of Dr. John Bower.  In October 2012, I joined the Bristol Chemical Synthesis CDT and have now started my PhD studies in the Bower group in collaboration with Pfizer. My research project involves the development of stereocontrolled strategies for the synthesis of chiral N-heterocyclic structures.

Publications:

  • C. S. Buxton, D. C. Blakemore and J. F. Bower; Reductive coupling of acrylates with ketones and ketimines via a nickel-catalyzed transfer hydrogenative strategy. Angew. Chem. Int. Ed. 2017, 56, 13824-13828.

Destination:

Research chemist at Evotec, Abingdon, UK.

Giacomo Crisenza

Giacomo Crisenza

I graduated in Chemistry in July 2010 from the University of Milan. My undergraduate research project was conducted with Prof. Dalla Croce. In 2011, I spent 5 months as an Erasmus student at the University of Valencia. I obtained my Master’s degree from the University of Milan in 2012, where my thesis project was with Prof. La Rosa.  In October 2012 I joined the Chemical Synthesis CDT at the University of Bristol and am now undertaking my PhD project in the Bower group. In my spare time I enjoy football and basketball.

Publications:

  • P. Cooper, G. E. M. Crisenza, L. J. Feron and J. F. Bower; Iridium-catalyzed α-selective arylation of styrenes by dual C-H functionalization. Angew. Chem. Int. Ed. 2018, 57, 14198-14202.
  • G. E. M. Crisenza, E. Dauncey and J. F. Bower; C2-Alkenylation of N-heteroaromatic compounds via Brønsted acid catalysis. Org. Biomol. Chem. 201614, 5820-5825. Invited contribution to the 2016 New Talent Special Issue.
  • G. E. M. Crisenza and J. F. Bower; Branch selective Murai-type alkene hydroarylation reactions. Chem. Lett. 2016, 45, 2-9.
  • G. E. M. Crisenza, O. O. Sokolova and J. F. Bower; Branch selective alkene hydroarylation via cooperative destabilization: iridium-catalyzed ortho-alkylation of acetanilides. Angew. Chem. 2015127, 15079-15083; Angew. Chem. Int. Ed. 201554, 14866-14870. 
  • G. E. M. Crisenza, N. G. McCreanor and J. F. Bower; Branch selective iridium-catalyzed hydroarylation of monosubstituted alkenes via a cooperative destabilization strategy. J. Am. Chem. Soc. 2014136, 10258-10261.

Awards, Prizes and Fellowships:

  • Faculty of Science PhD Thesis Commendation.
  • RSC postgraduate speaker at J-NOST-12, Central Drug Research Institute (CDRI), Lucknow, India, November 24-27, 2016.
  • Runner-up prize at the Third Year PhD Symposium, School of Chemistry, University of Bristol, May 4, 2016.
  • Runner-up prize at the RSC Organic Division Poster Symposium, Burlington House, London, November 30, 2015.
  • First prize at the second year “Syngenta Poster Competition”, April 29, 2015.
  • Second year poster presentation prize at the Bristol Synthesis CDT Summer Conference, July 8, 2014.

Destination:

Postdoctoral associate with Professor Paolo Melchiorre, ICIQ, Spain.

Niall McCreanor

Niall McCreanor

I attained an MSci in Chemistry from Queens University Belfast in 2011. My final year project was under the supervision of Dr. Matthew Cook developing new methods to medicinally relevant piperazines. I then joined the Bristol Chemical Synthesis CDT and I am now undertaking a PhD in the Bower group. My project entails the development of new rhodium catalysed multicomponent processes and their application to natural product synthesis.

Publications:

  • A. G. Dalling, T. Yamauchi, N. G. McCreanor, L. Cox and J. F. Bower; Carbonylative C-C bond activation of electron-poor cyclopropanes: rhodium-catalyzed (3+1+2) cycloadditions of cyclopropylamides. Angew. Chem. Int. Ed. 201958, 221-225.
  • G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504.
  • N. G. McCreanor, S. Stanton and J. F. Bower; Capture-collapse heterocyclization: 1,3-diazepanes by C-N reductive elimination from rhodacyclopentanones. J. Am. Chem. Soc. 2016, 138, 11465-11468.
  • M. H. Shaw, N. G. McCreanor, W. G. Whittingham and J. F. Bower; Reversible C-C bond activation enables stereocontrol in Rh-catalyzed carbonylative cycloadditions of aminocyclopropanes. J. Am. Chem. Soc. 2015, 137, 463-468.
  • G. E. M. Crisenza, N. G. McCreanor and J. F. Bower; Branch selective iridium-catalyzed hydroarylation of monosubstituted alkenes via a cooperative destabilization strategy. J. Am. Chem. Soc. 2014136, 10258-10261.

Awards, Prizes and Fellowships:

  • RSC postgraduate speaker at J-NOST-11, National Institute of Science Education and Research (NISER), Bhubaneswar, India, December 14-17, 2015.
  • Syngenta Postgraduate Scholarship Finalist, 2014.

Destination:

Research chemist at AstraZeneca, Macclesfield, UK.

Adele Faulkner

I obtained a MSci  in Chemistry with Industrial Experience from the University of Bristol. During my year in industry I worked for AstraZeneca at Avlon in the Process Chemistry department. My final year research project was with Dr John Bower exploring new methods to enable access to N-heterobicyclic scaffolds. I am now conducting my PhD project in collaboration with AstraZeneca.

Publications:

  • N. J. Race, I. R. Hazelden, A. Faulkner and J. F. Bower; Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles. Chem. Sci. 20178, 5248-5260.
  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, 8, 1981-1985.
  • N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513.
  • A. Faulkner, J. S. Scott and J. F. Bower; An umpolung approach to alkene carboamination: palladium catalyzed 1,2-amino-acylation, -carboxylation, ‑arylation, -vinylation and -alkynylation. J. Am. Chem. Soc. 2015, 137, 7224-7230.
  • A. Faulkner, N. J. Race, J. S. Scott and J. F. Bower; Copper catalyzed Heck-like cyclizations of oxime esters. Chem. Sci. 20145, 2416-2421.
  • A. Faulkner, J. S. Scott and J. F. Bower; Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol. Chem. Commun. 2013, 49, 1521-1523.
  • A. Faulkner and J. F. Bower; Highly efficient Narasaka-Heck cyclizations mediated by P(3,5-(CF3)2C6H3)3: facile access to N-heterobicyclic scaffolds. Angew. Chem. Int. Ed. 201251, 1675-1679.

Awards, Prizes and Fellowships:

  • Faculty of Science PhD Thesis Commendation.
  • Leverhulme Trust Study Abroad Fellowship, 2015.
  • Syngenta Postgraduate Scholarship Finalist, 2013.

Destination:

Postdoctoral associate with Professor Ben Feringa, Nobel Laureate, University of Groningen, Holland.

Megan Shaw

I graduated from the University of Sheffield with an MChem in Chemistry with Study in Industry. My industrial placement was with GlaxoSmithKline where I worked as a medicinal chemist. My final year research project was with Professor Joe Harrity working on the development of an enantiodivergent route to chiral amines. I then joined the Bristol Chemical Synthesis CDT and am now conducting my PhD project in the Bower group, where I am developing target directed asymmetric catalytic strategies in collaboration with Syngenta.

Publications:

  • G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504.
  • M. H. Shaw and J. F. Bower; Synthesis and applications of rhodacyclopentanones derived from C-C bond activation. Chem. Commun. 2016, 52, 10817-10829.
  • N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513.
  • M. H. Shaw, W. G. Whittingham and J. F. Bower; Directed carbonylative (3+1+2) cycloadditions of amino-substituted cyclopropanes and alkynes: reaction development and increased efficiencies using a cationic rhodium system. Tetrahedron 2016, 72, Symposium-in-print, Catalytic C–C bond formation by C–H functionalization and C–C bond cleavage, 2731-2741.
  • M. H. Shaw, R. A. Croft, W. G. Whittingham and J. F. Bower; Modular access to substituted azocanes via a rhodium-catalyzed cycloaddition-fragmentation strategy. J. Am. Chem. Soc. 2015, 137, 8054-8057.
  • M. H. Shaw, N. G. McCreanor, W. G. Whittingham and J. F. Bower; Reversible C-C bond activation enables stereocontrol in Rh-catalyzed carbonylative cycloadditions of aminocyclopropanes. J. Am. Chem. Soc. 2015, 137, 463-468.
  • M. H. Shaw, E. Y. Melikhova, D. P. Kloer, W. G. Whittingham and J. F. Bower; Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: rhodium catalyzed multicomponent synthesis of N-heterobicyclic enones. J. Am. Chem. Soc. 2013, 135, 4992-4995.

Awards, Prizes and Fellowships:

  • Faculty of Science PhD Thesis Commendation.
  • 2016 Reaxys PhD Prize Finalist (one of 45 selected worldwide).
  • RSC postgraduate speaker at J-NOST-10, Indian Institute of Technology, Chennai, India, December 4-6, 2014.
  • Best seminar prize at the RSC Heterocyclic and Synthesis Postgraduate Meeting, Vertex, Abingdon, September 16, 2014.
  • Best seminar prize, Third Year PhD Symposium, School of Chemistry,  University of Bristol, May 22, 2014.
  • Poster prize at the Syngenta Collaborative Research Conference, September 5-6, 2013.
  • “Synfacts” poster prize at OMCOS 17, Fort Collins, Colorado, USA, July 28 – August 1, 2013.

Destination:

Postdoctoral associate with Professor David MacMillan FRS, Princeton University, USA.

Nick Race

I achieved my undergraduate degree at the University of Oxford and did my final year research project with Professor Tim Donohoe where I expanded cross metathesis approaches to heteroaromatic compounds.  In 2010, I moved to Bristol to begin a PhD as part of the Bristol Chemical Synthesis CDT. Upon completion of the 8 month intensive training period I joined the Bower group to undertake my PhD project.  This involves the exploration of cascade approaches to complex N-heterocyclic structures.

Publications:

  • N. J. Race, I. R. Hazelden, A. Faulkner and J. F. Bower; Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles. Chem. Sci. 20178, 5248-5260.
  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, 8, 1981-1985.
  • N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513.
  • N. J. Race and J. F. Bower; Synthesis of heteroaromatic compounds by alkene and enyne metathesis. Top. Heterocycl. Chem. 2017, 47, 1-32.
  • A. Faulkner, N. J. Race, J. S. Scott and J. F. Bower; Copper catalyzed Heck-like cyclizations of oxime esters. Chem. Sci. 20145, 2416-2421.
  • N. J. Race and J. F. Bower; Palladium catalyzed cyclizations of oxime esters with 1,2-disubstituted alkenes: synthesis of dihydropyrroles. Org. Lett. 201315, 4616-4619.
  • T. J. Donohoe, N. J. Race, J. F. Bower and C. K. A. Callens; Substituted pyrroles via olefin cross-metathesis. Org. Lett. 2010, 12, 4094-4097.

Awards, Prizes and Fellowships:

  • Faculty of Science PhD Thesis Commendation.
  • Best seminar prize at the 25th South of England SCI Postgraduate Symposium on Novel Organic Chemistry, UCL, April 10, 2014.
  • 2013 SCI Postgraduate Scholarship.

Destination:

Postdoctoral associate with Professor Matthew Sigman, University of Utah, USA.

Qing Wang

I obtained a double degree in Chemistry and Chemical Engineering at National University of Ireland, Maynooth and Changzhou University. During my undergraduate studies, I researched the synthesis and characterisation of pharmaceutical intermediates with Prof. Dr. Chen in China, 2009. Then, in 2010, I transferred to NUIM and was awarded my BSc (Hons) (1st Class). Now I am a graduate student in Bristol working in the Bower Group on the synthesis of nitrogen heterocycles by new catalytic C-N bond forming reactions.

Destination:

PhD studies with Professor P. Andrew Evans, Queen’s University Ontario, Canada.


Postdoctoral Associates

Javier García Cárceles

I graduated from Universidad Complutense de Madrid in 2012 with an MSci in Organic Chemistry. I then carried out my PhD studies under the supervision of Prof. María Luz López Rogríguez in the Medicinal Chemistry Laboratory (UCM) working on the development of new allosteric modulators of G protein-coupled receptors (GPCRs), where I also took a postdoctoral position in 2017. In January 2018, I moved to the Bower group where I am developing novel methods for C-C bond activation.

Publications:

  • B. T. Jones, J. García-Cárceles, L. Caiger, I. R. Hazelden, R. J. Lewis, T. Langer and J. F. Bower; Complex polyheterocycles and the stereochemical reassignment of pileamartine A via aza-Heck triggered aryl C-H functionalization cascades. J. Am. Chem. Soc. 2021, In press.
  • J. García-Cárceles, K. A. Bahou, and J. F. Bower; Recent methodologies that exploit oxidative addition of C-N bonds to transition metals. ACS Catalysis 2020, 10, 12738-12759.

Awards, Prizes and Fellowships:

  • Fundación Alfonso Martín Escudero Postdoctoral Fellowship, 2017.

James Wood

I obtained my BSc from the University of Auckland in 2014, before undertaking a PhD there with Distinguished Professor Margaret Brimble and Dr Daniel Furkert. My research focussed on the synthesis of 2-formylpyrrole natural products using a novel Maillard-type reaction. In June 2018 I joined the Bower  group where I am developing novel methods for naphthoquinone synthesis in collaboration with Prof. Eufrânio da Silva Jr. Outside of the lab I enjoy cricket, Friday beers and hiking.

Publications:

  • J. M. Wood, N. S. Satam, R. G. Almeida, V. S. Cristani, D. P. Lima, L. D. Pereira, K. Salomão, R. F. S. Menna-Barreto, I. N. N. Namboothiri, J. F. Bower and E. N. da Silva Júnior; Strategies towards potent trypanocidal drugs: application of Rh-catalyzed [2+2+2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi. Bioorg. Med. Chem. 202028, 115565.
  • J. M. Wood, E. N. da Silva Júnior and J. F. Bower; Rh-catalyzed [2+2+2] cycloadditions with benzoquinones: de novo access to naphthoquinones for lignan and type II polyketide synthesis. Org. Lett. 2020, 22, 265-269.

Destination:

Postdoctoral associate at the Ferrier Institute, Victoria University, Wellington, New Zealand.

Gangwei Wang

Gangwei WangI obtained my MSci degree in 2010 from Lanzhou University. I then undertook PhD studies in Prof. Yang Shangdong’s group at the State Key Laboratory of Applied Organic Chemistry, Lanzhou University. During this time, my research focused on the development and mechanism of new metal-catalyzed C-H bond functionalisations to construct C-X bonds (X = C, N, O). In August 2015, I started my first postdoctoral appointment in the Bower group, where I am working on new C-C bond activation methodologies.

Publications:

  • G.-W. Wang, O. O. Sokolova, T. A. Young, E. M. S. Christodoulou, C. P. Butts and J. F. Bower; Carbonylative C-C bond activation of aminocyclopropanes using a temporary directing group strategy. J. Am. Chem. Soc. 2020, 142, 19006-19011.
  • G.-W. Wang, O. Boyd, T. A. Young, S. M. Bertrand and J. F. Bower; Rhodacyclopentanones as linchpins for the atom economical assembly of diverse polyheterocycles. J. Am. Chem. Soc. 2020, 142, 1740-1745.
  • O. Boyd, G.-W. Wang, O. O. Sokolova, A. D. J. Calow, S. M. Bertrand and J. F. Bower; Modular access to eight-membered N-heterocycles by directed carbonylative C-C bond activation of aminocyclopropanes. Angew. Chem. Int. Ed. 2019, 58, 18844-18848.
  • G.-W. Wang and J. F. Bower; Modular access to azepines by directed carbonylative C-C bond activation of aminocyclopropanes. J. Am. Chem. Soc. 2018, 140, 2743-2747.
  • G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504.

Awards, Prizes and Fellowships:

  • Royal Society K. C. Wong Postdoctoral Fellowship, 2015.

Destination:

Postdoctoral associate with Professor Igor Larrosa, University of Manchester, UK.

Xiaofeng Ma

Xiaofeng MaI obtained my PhD degree in 2012 from Chengdu Institute of Biology, Chinese Academy of Sciences under the supervision of Prof. Shao Huawu. I then moved on to a postdoctoral position in Prof. I. E. Marko’s group in Universite catholique de Louvain, where I designed new inibitors for GABA transporters. I also worked on organic electrochemistry, photochemistry and some other industry projects. In March 2016, I joined the Bower Group, where I am working on new C-N bond forming cascades.

Publications:

  • X. Ma, I. R. Hazelden, T. Langer, R. H. Munday and J. F. Bower; Enantioselective aza-Heck cyclizations of N-(tosyloxy)carbamates: synthesis of pyrrolidines and piperidines. J. Am. Chem. Soc. 2019, 141, 3356-3360.
  • X. Ma, J. J. Farndon, T. Young, N. Fey and J. F. Bower; A simple and broadly applicable C-N bond forming dearomatization protocol enabled by bifunctional amino-reagents. Angew. Chem. Int. Ed. 2017, 56, 14531-14535.
  • J. J. Farndon, X. Ma and J. F. Bower; Transition metal free C-N bond forming dearomatizations and aryl C-H aminations by in situ release of a hydroxylamine-based aminating agent. J. Am. Chem. Soc. 2017, 139, 14005-14008.
  • I. R. Hazelden, X. Ma, T. Langer and J. F. Bower; Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides. Angew. Chem. 2016, 128, 11364-11368; Angew. Chem. Int. Ed. 2016, 55, 11198-11202.

Destination:

Professor at Chengdu Institute of Biology, Chinese Academy of Sciences.

Rajender Nallagonda

My M.Sc. degree (2009) was from Osmania University, Hyderabad. I was then a research scientist at GVK Bio science PVT LTD. My PhD  (2016) was under the supervision of Prof. Prasanta Ghorai at the ‘Indian Institute of Science Education and Research Bhopal’, where I researched transition metal-catalysed C-C, C-N and C-O bond forming reactions. Subsequently, I worked at ‘IIT Bombay’ with Prof. Chandra. M. R. Volla and at the ‘HUJI’ with Dr. Ahmad Masarwa.  In February 2018, I moved to the Bower group where I work on aryl C-H functionalisation.

Awards, Prizes and Fellowships:

  • SERB-India Overseas Postdoctoral Fellowship, 2018.

Simon Grélaud

I obtained a Masters degree in Molecular and Macromolecular chemistry from the University of Bordeaux in 2013. I then did a PhD under the supervision of Pr. Y. Landais where I developed new methodology, based on diastereoselective radical acylation, to access polysubstituted tetrahydrofuran and pyrrolidine moieties. In January 2017, I started a postdoctoral position in the Bower group, working on aryl C-H functionalisation. Outside of the lab, I enjoy playing football or badminton, spending time with friends and having a glass of good red wine.

Publications:

  • S. Grélaud, P. Cooper, L. J. Feron and J. F. Bower; Branch-selective and enantioselective iridium-catalyzed alkene hydroarylation via anilide-directed C-H oxidative addition.  J. Am. Chem. Soc. 2018, 140, 9351-9356.

Destination:

Research chemist at StrainChem, France.

Adam Calow

I obtained my MChem (1st Class) in 2011 from the University of Hull. I then moved to Durham University for a PhD with Prof. Andy Whiting, where I investigated new routes to 1,3-amino alcohols. Some of this research was undertaken in the laboratory of Prof. M. E. Fernández. In 2015, I moved to the Max Planck Institute in Berlin (now Potsdam) to work with Prof. P. Seeberger on the synthesis of glycoconjugate vaccines. In October 2016, I moved to the Bower group where I am developing novel methods for C-C bond activation.

Publications:

  • O. Boyd, G.-W. Wang, O. O. Sokolova, A. D. J. Calow, S. M. Bertrand and J. F. Bower; Modular access to eight-membered N-heterocycles by directed carbonylative C-C bond activation of aminocyclopropanes. Angew. Chem. Int. Ed. 201958, 18844-18848.
  • A. D. J. Calow and J. F. Bower; Rhodium(I)-catalyzed reductive carbon-carbon bond formation in Rhodium catalysis in organic synthesis: methods and reactions, K. Tanaka (Ed.), Wiley-VCH, 2019, pp 133-160.

Destination:

Medicinal chemist at Evotec, Abingdon, UK.

Takayuki Yamauchi

Takayuki Yamauchi

I obtained my PhD degree in March 2016 from Gifu University under the supervision of Professor Toshiaki Murai and Professor Fumitoshi Shibahara. During this time my research focused on the development of C-H bond functionalization methods to provide easy access to multi-functionalized heteroarenes. I then joined the Bower group where I am working on cross-coupling reactions triggered by C-N bond activation. In my spare time I enjoy tennis.

 Publications:

  • A. G. Dalling, T. Yamauchi, N. G. McCreanor, L. Cox and J. F. Bower; Carbonylative C-C bond activation of electron-poor cyclopropanes: rhodium-catalyzed (3+1+2) cycloadditions of cyclopropylamides. Angew. Chem. Int. Ed. 2019, 58, 221-225.
  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, 8, 1981-1985.

Awards, Prizes and Fellowships:

  • JSPS Fellowship.

Gabriele Fumagalli

Gabriele Fumagalli

I obtained my BSc (2009) from the Università degli Studi in Milan and my MSc (2011) in Organic Chemistry from the same institution. My PhD studies were conducted in collaboration with AstraZeneca at the University of Manchester, where I developed photoredox catalysed methodologies for the synthesis of small, highly functionalised molecules under the supervision of Prof. Mike Greaney. In September 2015, I started postdoctoral work in the Bower Group, where I am developing Rh-catalysed carbonylative ring-expansions.

Publications:

  • G. Fumagalli, S. Stanton and J. F. Bower; Recent methodologies that exploit C-C single bond cleavage of strained ring systems by transition metal complexes. Chem. Rev. 2017, 117, 9404-9432. Invited contribution to the 2017 thematic issue on C-H and C-C functionalisation.
  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, 8, 1981-1985.

Destination:

Medicinal chemist at AstraZeneca, Cambridge, UK.


Co-Supervised and Visiting Postgraduate Students

Jamie Cadge

I graduated from the University of Nottingham in 2016 with an MSci degree. After completing summer placements with Dr J. Dowden and at GSK, my final year project was with Dr L. Ball, developing methodology for aromatic fluorinations. I then moved to Bristol to join the Chemical Synthesis CDT, where I am working on the development of Au-catalysed C-X bond formations under the supervision of Dr Chris Russell, Dr John Bower and Prof. Didier Bourissou (University of Toulouse). In my spare time I enjoy watching films, live music and playing the piano.

Publications:

  • J. A. Cadge, J. F. Bower and C. A. Russell; A systematic study of the effects of complex structure on aryl iodide oxidative addition at bipyridyl-ligated Au(I) centers. Angew. Chem. Int. Ed. 2021, In press.
  • J. A. Cadge, H. A. Sparkes, J. F. Bower and C. A. Russell; Oxidative addition of alkenyl and alkynyl iodides to a Au(I) complex. Angew. Chem. Int. Ed. 2020, 59, 6617-6621.

Awards, Prizes and Fellowships:

  • Poster prize at the Mechanistic processes in organometallic chemistry Faraday Discussion, University of York, September 2-4, 2019.
  • Poster prize at the Oxford Synthesis Summer Conference, Oxford, June 25-26, 2018.

Matthew Harper

Matt Harper

I graduated from the University of Bristol in 2013 with a BSc in Chemistry, investigating boron chemistry with Professor Guy Lloyd-Jones for my final year project. I then stayed at Bristol for an MSc by research, working with Dr. Carmen Galan on alpha-selective organocatalytic glycosylations. I am now working on oxidative gold catalysis under the supervision of Dr. Chris Russell and Dr. John Bower, in collaboration with Syngenta. In my spare time, I enjoy cycling, photography and cooking.

Publications:

  • M. J. Harper, C. J. Arthur, J. Crosby, E. J. Emmett, R. L. Falconer, A. J. Fensham-Smith, P. J. Gates, T. Leman, J. E. McGrady, J. F. Bower and C. A. Russell; Oxidative addition, transmetallation and reductive elimination at a 2,2′-bipyridyl ligated gold center. J. Am. Chem. Soc. 2018, 140, 2743-2757.
  • M. J. Harper, E. J. Emmett, J. F. Bower and C. A. Russell; Oxidative 1,2-difunctionalization of ethylene via gold-catalyzed oxyarylation. J. Am. Chem. Soc. 2017, 139, 12386-12389.

Awards, Prizes and Fellowships:

  • Faculty of Science PhD Thesis Commendation.
  • Best “molecular chemistry” seminar prize at the Inorganic and Materials Postgraduate Symposium, School of Chemistry, University of Bristol, June 25, 2018.
  • Poster prize at the Syngenta Collaborative Research Conference, September 7-8, 2017.
  • Poster prize at the European Chemical Sciences Division of Organometallic Chemistry Conference (EuCOMC), Amsterdam, Netherlands, July 9-13, 2017.

Destination:

Postdoctoral associate with Professor Timothy Gallagher, University of Bristol.

Guto Rhys

Guto RhysI graduated from Imperial College, London in 2012 with an MSci in Chemistry with a Year in Industry. I then joined the Bristol Chemical Synthesis CDT, where I am conducting my PhD project under the supervision of Prof. Dek Woolfson, Dr. John Bower and Prof. Leo Brady. My project involves investigations into protein design and the functionalisation of coiled-coil peptide assemblies to generate de novo catalytic systems. In my spare time I like watching live music and composing.

Awards, Prizes and Fellowships:

  • Faculty of Science PhD Thesis Commendation.

Rafaela Carmona

Rafaela Carmona

I obtained my BSc from the Federal University of Sao Carlos-Brazil in 2011. In 2013, I completed my MSc at the University of Sao Paulo, with Prof. Alcindo A. Dos Santos, developing metal-catalyzed multicomponent asymmetric reactions. I then joined Prof. Carlos Roque D. Correia’s group at UNICAMP to start my PhD project on asymmetric Heck-Matsuda reactions. I am currently undertaking a 12 month placement at Bristol, researching aza-Heck cyclisations. In my spare time I enjoy running, meeting friends and traveling.

Publications:

  • I. R. Hazelden, R. C. Carmona, T. Langer, P. G. Pringle and J. F. Bower; Pyrrolidines and piperidines by ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates. Angew. Chem. Int. Ed. 2018, 57, 5124-5128.

Alexander Henderson

Alex Henderson

I obtained my MSci in Chemistry from the University of Bristol in 2011 and was awarded the DuPont prize. I did my final year project with Dr John Bower and spent my third year at the University of Texas at Austin where I worked with Prof. Michael Krische. I subsequently joined the Bristol Chemical Synthesis CDT and am conducting a PhD project, co-supervised with Dr. Carmen Galan, researching  carbohydrate-based ligand systems. Out of the laboratory I am a keen photographer and enjoy racquet sports.

Publications:

  • A. S. Henderson, J. F. Bower and M. C. Galan; Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination. Org. Biomol. Chem. 2020, 18, 3012-3016.
  • A. S. Henderson, J. F. Bower and M. C. Galan; Carbohydrates as enantioinduction components in stereoselective catalysis. Org. Biomol. Chem. 2016, 14, 4008-4017.
  • A. S. Henderson, S. Medina, J. F. Bower and M. C. Galan; Nucleophilic aromatic substitution as an approach to challenging carbohydrate-aryl ethers. Org. Lett. 2015, 17, 4846-4849.
  • S. Medina, A. S. Henderson, J. F. Bower and M. C. Galan; Stereoselective synthesis of glycosides using (salen)Co catalysts as promoters. Chem. Commun. 2015, 51, 8939-8941.
  • A. S. Henderson, J. F. Bower and M. C. Galan; Carbohydrate-based N-heterocyclic carbenes for enantioselective catalysis. Org. Biomol. Chem. 201412, 9180-9183.

Awards, Prizes and Fellowships:

  • 2013 JSPS Fellowship (3 month placement at Kyoto University with Prof. S. Matsubara).

Destination:

Patent attorney with Carpmaels & Ransford, London, UK.

Guilherme Augusto de Melo Jardim

Guilherme

I graduated in Chemistry in 2013 from the Federal University of Minas Gerais. In 2014 I got my MSc degree in organic chemistry from the same university under the supervision of Dr Eufrânio da Silva Jr. I am currently a PhD student at Bristol University under the joint supervision of Dr John Bower and Dr Eufrânio da Silva Jr. My project aims are the development of new synthetic methodologies applied to naphthoquinoidal substances.

Publications:

  • G. A. M. Jardim, T. L. da Silva, M. O. F. Goulart, C. A. de Simone, J. M. C. Barbosa, K. Salomão, S. L. de Castro, J. F. Bower and E. N. da Silva Júnior; Eur. J. Med. Chem. 2017136, 406-419.
  • G. A. M. Jardim, J. F. Bower and E. N. da Silva Júnior; Rh-catalyzed reactions of 1,4-benzoquinones with electrophiles: C-H iodination, bromination and phenylselenation. Org. Lett. 2016, 18, 4454-4457.
  • G. A. M. Jardim, E. N. da Silva Júnior and J. F. Bower; Overcoming naphthoquinone deactivation: rhodium-catalyzed C-5 selective C-H iodination as a gateway to functionalized derivatives. Chem. Sci. 2016, 7, 3780-3784.

Undergraduate and Visiting Students

Silas Aslan Johnathan Matlock Ekaterina Melikhova
Silas Aslan

Erasmus student – 2010/11
Johnathan Matlock

DTC RBS student – 2010/11
Ekaterina Melikhova

Summer student – 2011
Antony Burton Sam Timson
Antony Burton

DTC RBS student – 2011/12
Michael Ralph

DTC RBS student – 2011/12
Sam Timson

DTC RBS student – 2011/12
Donald Hill Sarah Narramore Jason Hui
Donald Hill

MSci student – 2011/12
Sarah Narramore

MSci student – 2011/12
Jason Hui

Summer student – 2012
David Wheatley Kelly Bass Emma Blackham
David Wheatley

Summer student – 2012
Kelly Bass 

DTC RBS student – 2012/13 
Emma Blackham 

DTC RBS student – 2012/13
Robert Tromans Robert Mothershaw Alina Lyuleeva
Robert Tromans

MSci student – 2012/13
Robert Mothershaw 

MSci student – 2012/13
Alina Lyuleeva

Erasmus student – 2012/13
Sree Gayathri Richard Butcher James Smith
Sree Gayathri

Summer student – 2013
Richard Butcher

Summer student – 2013
James Smith

CDT RBS student – 2013/14
Takayuki Yamauchi Rosie Falconer Will Yu
Takayuki Yamauchi

Visiting PhD student- 2013/14
Rosie Falconer

CDT RBS Student – 2013/14
Will Yu

CDT RBS Student – 2013/14
Alex Brown Rosie Croft Mariana Soares Costa
Alex Brown

MSci student – 2013/14
Rosie Croft

MSci student – 2013/14
Mariana Soares Costa

Visiting Undergraduate – 2013/14
Bin Zhou Elizabeth Dauncey Anna Chamberlain
Bin Zhou

CDT RBS student – 2014/15
Elizabeth Dauncey

MSci student – 2014/15
Anna Chamberlain

MSci student – 2014/15
Ellen Watts David Morris Beth Glaisyer
Ellen Watts

MSci student – 2014/15
David Morris

CDT RBS student – 2015/16
Beth Glaisyer

CDT RBS student – 2015/16
Taniya Shandil Alex Williams
Ailis Chadwick

CDT RBS student – 2015/16
Taniya Shandil

CDT RBS student – 2015/16
Alex Williams

MSci student – 2015/16
Peter Clark
Peter Clark

MSci student – 2015/16
Lewis Smith

MSci student – 2016/17
 Jordan Kelly

MSci student – 2016/17
Joseph Barker Tom Young Mark Deeprose
Joseph Barker

CDT RBS student – 2016/17
Tom Young

Summer student – 2017
Mark Deeprose

CDT RBS student – 2017/18
Joseph Abell

CDT RBS student – 2017/18
Lydia Cox

MSci student – 2017/18
Ellie Lester

MSci student – 2017/18
Aidan McFord

CDT RBS student – 2018/19
Hao Lan

CDT RBS student – 2018/19
Matthew Williams

CDT RBS student – 2018/19
Jacob Burley

MSci student – 2018/19
Rachael Ambler

MSci student – 2018/19
Lewis Caiger

MSci student – 2018/19
Bert Rowett

CDT RBS student – 2018/19
Hector Christodoulou

Summer student – 2019
Matty Curley

MSci student – 2019/20
Nicholas Hodson

MSci student – 2019/20
Aaron King

MSci student – 2019/20
Josh Thomson

MSci student – 2019/20