Former Members

Postgraduate Students

Niall McCreanor

Niall McCreanor

I attained an MSci in Chemistry from Queens University Belfast in 2011. My final year project was under the supervision of Dr. Matthew Cook developing new methods to medicinally relevant piperazines. I then joined the Bristol Chemical Synthesis CDT and I am now undertaking a PhD in the Bower group. My project entails the development of new rhodium catalysed multicomponent processes and their application to natural product synthesis.

Publications:

  • G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504.
  • N. G. McCreanor, S. Stanton and J. F. Bower; Capture-collapse heterocyclization: 1,3-diazepanes by C-N reductive elimination from rhodacyclopentanones. J. Am. Chem. Soc. 2016, 138, 11465-11468.
  • M. H. Shaw, N. G. McCreanor, W. G. Whittingham and J. F. Bower; Reversible C-C bond activation enables stereocontrol in Rh-catalyzed carbonylative cycloadditions of aminocyclopropanes. J. Am. Chem. Soc. 2015, 137, 463-468.
  • G. E. M. Crisenza, N. G. McCreanor and J. F. Bower; Branch selective iridium-catalyzed hydroarylation of monosubstituted alkenes via a cooperative destabilization strategy. J. Am. Chem. Soc. 2014136, 10258-10261.

Awards, Prizes and Fellowships:

  • RSC postgraduate speaker at J-NOST-11, National Institute of Science Education and Research (NISER), Bhubaneswar, India, December 14-17, 2015.
  • Syngenta Postgraduate Scholarship Finalist, 2014.

Destination:

Research chemist at AstraZeneca, Macclesfield, UK.

Adele Faulkner

I obtained a MSci  in Chemistry with Industrial Experience from the University of Bristol. During my year in industry I worked for AstraZeneca at Avlon in the Process Chemistry department. My final year research project was with Dr John Bower exploring new methods to enable access to N-heterobicyclic scaffolds. I am now conducting my PhD project in collaboration with AstraZeneca.

Publications:

  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, In press.
  • N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513.
  • A. Faulkner, J. S. Scott and J. F. Bower; An umpolung approach to alkene carboamination: palladium catalyzed 1,2-amino-acylation, -carboxylation, ‑arylation, -vinylation and -alkynylation. J. Am. Chem. Soc. 2015, 137, 7224-7230.
  • A. Faulkner, N. J. Race, J. S. Scott and J. F. Bower; Copper catalyzed Heck-like cyclizations of oxime esters. Chem. Sci. 20145, 2416-2421.
  • A. Faulkner, J. S. Scott and J. F. Bower; Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol. Chem. Commun. 2013, 49, 1521-1523.
  • A. Faulkner and J. F. Bower; Highly efficient Narasaka-Heck cyclizations mediated by P(3,5-(CF3)2C6H3)3: facile access to N-heterobicyclic scaffolds. Angew. Chem. Int. Ed. 201251, 1675-1679.

Awards, Prizes and Fellowships:

  • Leverhulme Trust Study Abroad Fellowship, 2015.
  • Syngenta Postgraduate Scholarship Finalist, 2013.

Destination:

Postdoctoral associate with Professor Ben Feringa, Nobel Laureate, University of Groningen, Holland.

Megan Shaw

I graduated from the University of Sheffield with an MChem in Chemistry with Study in Industry. My industrial placement was with GlaxoSmithKline where I worked as a medicinal chemist. My final year research project was with Professor Joe Harrity working on the development of an enantiodivergent route to chiral amines. I then joined the Bristol Chemical Synthesis CDT and am now conducting my PhD project in the Bower group, where I am developing target directed asymmetric catalytic strategies in collaboration with Syngenta.

Publications:

  • G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504.
  • M. H. Shaw and J. F. Bower; Synthesis and applications of rhodacyclopentanones derived from C-C bond activation. Chem. Commun. 2016, 52, 10817-10829.
  • N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513.
  • M. H. Shaw, W. G. Whittingham and J. F. Bower; Directed carbonylative (3+1+2) cycloadditions of amino-substituted cyclopropanes and alkynes: reaction development and increased efficiencies using a cationic rhodium system. Tetrahedron 2016, 72, Symposium-in-print, Catalytic C–C bond formation by C–H functionalization and C–C bond cleavage, 2731-2741.
  • M. H. Shaw, R. A. Croft, W. G. Whittingham and J. F. Bower; Modular access to substituted azocanes via a rhodium-catalyzed cycloaddition-fragmentation strategy. J. Am. Chem. Soc. 2015, 137, 8054-8057.
  • M. H. Shaw, N. G. McCreanor, W. G. Whittingham and J. F. Bower; Reversible C-C bond activation enables stereocontrol in Rh-catalyzed carbonylative cycloadditions of aminocyclopropanes. J. Am. Chem. Soc. 2015, 137, 463-468.
  • M. H. Shaw, E. Y. Melikhova, D. P. Kloer, W. G. Whittingham and J. F. Bower; Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: rhodium catalyzed multicomponent synthesis of N-heterobicyclic enones. J. Am. Chem. Soc. 2013, 135, 4992-4995.

Awards, Prizes and Fellowships:

  • 2016 Reaxys PhD Prize Finalist (one of 45 selected worldwide).
  • RSC postgraduate speaker at J-NOST-10, Indian Institute of Technology, Chennai, India, December 4-6, 2014.
  • Best seminar prize at the RSC Heterocyclic and Synthesis Postgraduate Meeting, Vertex, Abingdon, September 16, 2014.
  • Best seminar prize, Third Year PhD Symposium, School of Chemistry,  University of Bristol, May 22, 2014.
  • Poster prize at the Syngenta Collaborative Research Conference, September 5-6, 2013.
  • “Synfacts” poster prize at OMCOS 17, Fort Collins, Colorado, USA, July 28 – August 1, 2013.

Destination:

Postdoctoral associate with Professor David MacMillan FRS, Princeton University, USA.

Nick Race

I achieved my undergraduate degree at the University of Oxford and did my final year research project with Professor Tim Donohoe where I expanded cross metathesis approaches to heteroaromatic compounds.  In 2010, I moved to Bristol to begin a PhD as part of the Bristol Chemical Synthesis CDT. Upon completion of the 8 month intensive training period I joined the Bower group to undertake my PhD project.  This involves the exploration of cascade approaches to complex N-heterocyclic structures.

Publications:

  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, In press.
  • N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513.
  • N. J. Race and J. F. Bower; Synthesis of heteroaromatic compounds by alkene and enyne metathesis. Top. Heterocycl. Chem. DOI: 10.1007/7081_2015_145.
  • A. Faulkner, N. J. Race, J. S. Scott and J. F. Bower; Copper catalyzed Heck-like cyclizations of oxime esters. Chem. Sci. 20145, 2416-2421.
  • N. J. Race and J. F. Bower; Palladium catalyzed cyclizations of oxime esters with 1,2-disubstituted alkenes: synthesis of dihydropyrroles. Org. Lett. 201315, 4616-4619.
  • T. J. Donohoe, N. J. Race, J. F. Bower and C. K. A. Callens; Substituted pyrroles via olefin cross-metathesis. Org. Lett. 2010, 12, 4094-4097.

Awards, Prizes and Fellowships:

Destination:

Postdoctoral associate with Professor Matthew Sigman, University of Utah, USA.

Qing Wang

I obtained a double degree in Chemistry and Chemical Engineering at National University of Ireland, Maynooth and Changzhou University. During my undergraduate studies, I researched the synthesis and characterisation of pharmaceutical intermediates with Prof. Dr. Chen in China, 2009. Then, in 2010, I transferred to NUIM and was awarded my BSc (Hons) (1st Class). Now I am a graduate student in Bristol working in the Bower Group on the synthesis of nitrogen heterocycles by new catalytic C-N bond forming reactions.

Destination:

PhD studies with Professor P. Andrew Evans, Queen’s University Ontario, Canada.


Postdoctoral Associates

Gabriele Fumagalli

Gabriele Fumagalli

I obtained my BSc (2009) from the Università degli Studi in Milan and my MSc (2011) in Organic Chemistry from the same institution. My PhD studies were conducted in collaboration with AstraZeneca at the University of Manchester, where I developed photoredox catalysed methodologies for the synthesis of small, highly functionalised molecules under the supervision of Prof. Mike Greaney. In September 2015, I started postdoctoral work in the Bower Group, where I am developing Rh-catalysed carbonylative ring-expansions.

Publications:

  • G. Fumagalli, S. Stanton and J. F. Bower; Recent methodologies that exploit C-C single bond cleavage of strained ring systems by transition metal complexes. Chem. Rev. 2017, In press. Invited contribution to the 2017 thematic issue on C-H and C-C functionalisation.
  • N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, In press.

Destination:

Medicinal chemist at AstraZeneca, Cambridge, UK.


Co-Supervised Postgraduate Students

Alexander Henderson

Alex Henderson

I obtained my MSci in Chemistry from the University of Bristol in 2011 and was awarded the DuPont prize. I did my final year project with Dr John Bower and spent my third year at the University of Texas at Austin where I worked with Prof. Michael Krische. I subsequently joined the Bristol Chemical Synthesis CDT and am conducting a PhD project, co-supervised with Dr. Carmen Galan, researching  carbohydrate-based ligand systems. Out of the laboratory I am a keen photographer and enjoy racquet sports.

Publications:

  • A. S. Henderson, J. F. Bower and M. C. Galan; Carbohydrates as enantioinduction components in stereoselective catalysis. Org. Biomol. Chem. 2016, 14, 4008-4017.
  • A. S. Henderson, S. Medina, J. F. Bower and M. C. Galan; Nucleophilic aromatic substitution as an approach to challenging carbohydrate-aryl ethers. Org. Lett. 2015, 17, 4846-4849.
  • S. Medina, A. S. Henderson, J. F. Bower and M. C. Galan; Stereoselective synthesis of glycosides using (salen)Co catalysts as promoters. Chem. Commun. 2015, 51, 8939-8941.
  • A. S. Henderson, J. F. Bower and M. C. Galan; Carbohydrate-based N-heterocyclic carbenes for enantioselective catalysis. Org. Biomol. Chem. 201412, 9180-9183.

Awards, Prizes and Fellowships:

  • 2013 JSPS Fellowship (3 month placement at Kyoto University with Prof. S. Matsubara).

Destination:

Patent attorney with Carpmaels & Ransford, London, UK.

Guilherme Augusto de Melo Jardim

Guilherme

I graduated in Chemistry in 2013 from the Federal University of Minas Gerais. In 2014 I got my MSc degree in organic chemistry from the same university under the supervision of Dr Eufrânio da Silva Jr. I am currently a PhD student at Bristol University under the joint supervision of Dr John Bower and Dr Eufrânio da Silva Jr. My project aims are the development of new synthetic methodologies applied to naphthoquinoidal substances.

Publications:

  • G. A. M. Jardim, J. F. Bower and E. N. da Silva Júnior; Rh-catalyzed reactions of 1,4-benzoquinones with electrophiles: C-H iodination, bromination and phenylselenation. Org. Lett. 2016, 18, 4454-4457.
  • G. A. M. Jardim, E. N. da Silva Júnior and J. F. Bower; Overcoming naphthoquinone deactivation: rhodium-catalyzed C-5 selective C-H iodination as a gateway to functionalized derivatives. Chem. Sci. 2016, 7, 3780-3784.

Undergraduate and Visiting Students

Silas Aslan Johnathan Matlock Ekaterina Melikhova
Silas Aslan

Erasmus student – 2010/11
Johnathan Matlock

DTC RBS student – 2010/11
Ekaterina Melikhova

Summer student – 2011
Antony Burton Sam Timson
Antony Burton

DTC RBS student – 2011/12
Michael Ralph

DTC RBS student – 2011/12
Sam Timson

DTC RBS student – 2011/12
Donald Hill Sarah Narramore Jason Hui
Donald Hill

MSci student – 2011/12
Sarah Narramore

MSci student – 2011/12
Jason Hui

Summer student – 2012
David Wheatley Kelly Bass Emma Blackham
David Wheatley

Summer student – 2012
Kelly Bass 

DTC RBS student – 2012/13 
Emma Blackham 

DTC RBS student – 2012/13
Robert Tromans Robert Mothershaw Alina Lyuleeva
Robert Tromans

MSci student – 2012/13
Robert Mothershaw 

MSci student – 2012/13
Alina Lyuleeva

Erasmus student – 2012/13
Sree Gayathri Richard Butcher James Smith
Sree Gayathri

Summer student – 2013
Richard Butcher

Summer student – 2013
James Smith

CDT RBS student – 2013/14
Takayuki Yamauchi Rosie Falconer Will Yu
Takayuki Yamauchi

Visiting PhD student- 2013/14
Rosie Falconer

CDT RBS Student – 2013/14
Will Yu

CDT RBS Student – 2013/14
Alex Brown Rosie Croft Mariana Soares Costa
Alex Brown

MSci student – 2013/14
Rosie Croft

MSci student – 2013/14
Mariana Soares Costa

Visiting Undergraduate – 2013/14
Bin Zhou Elizabeth Dauncey Anna Chamberlain
Bin Zhou

CDT RBS student – 2014/15
Elizabeth Dauncey

MSci student – 2014/15
Anna Chamberlain

MSci student – 2014/15
Ellen Watts David Morris Beth Glaisyer
Ellen Watts

MSci student – 2014/15
David Morris

CDT RBS student – 2015/16
Beth Glaisyer

CDT RBS student – 2015/16
Taniya Shandil Alex Williams
Ailis Chadwick

CDT RBS student – 2015/16
Taniya Shandil

CDT RBS student – 2015/16
Alex Williams

MSci student – 2015/16
Peter Clark
Peter Clark

MSci student – 2015/16