Publications

64. X. Ma, J. J. Farndon, T. Young, N. Fey and J. F. Bower*; A simple and broadly applicable C-N bond forming dearomatization protocol enabled by bifunctional amino reagents. Angew. Chem. Int. Ed. 2017, In press. (open access)

63. J. J. Farndon, X. Ma and J. F. Bower*; Transition metal free C-N bond forming dearomatizations and aryl C-H aminations by in situ release of a hydroxylamine-based aminating agent. J. Am. Chem. Soc. 2017, In press. (open access)

62. M. J. Harper, E. J. Emmett, J. F. Bower* and C. A. Russell*; Oxidative 1,2-difunctionalization of ethylene via gold-catalyzed oxyarylation. J. Am. Chem. Soc. 2017, In press. (open access)

Abstract Image

61. C. S. Buxton, D. C. Blakemore and J. F. Bower*; Reductive coupling of acrylates with ketones and ketimines by a nickel-catalyzed transfer hydrogenative strategy. Angew. Chem. Int. Ed. 2017, In press. (open access)

60. N. J. Race, I. R. Hazelden, A. Faulkner and J. F. Bower*; Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles. Chem. Sci. 2017, 8, 5248-5260. (open access)

59. G. A. M. Jardim, T. L. da Silva, M. O. F. Goulart, C. A. de Simone, J. M. C. Barbosa, K. Salomão, S. L. de Castro, J. F. Bower and E. N. da Silva Júnior*; Rhodium-catalyzed C-H bond activation for the synthesis of quinonoid compounds: significant anti-Trypanosoma cruzi activities and electrochemical studies of functionalized quinones. Eur. J. Med. Chem. 2017, 136, 406-419.

58. N. J. Race, A. Faulkner, G. Fumagalli, T. Yamauchi, J. S. Scott, M. Rydén-Landergren, H. A. Sparkes and J. F. Bower*; Enantioselective Narasaka-Heck cyclizations: synthesis of tetrasubstituted nitrogen-bearing stereocenters. Chem. Sci. 2017, 8, 1981-1985. (open access; Highlighted in SYNFACTS 2017, 182; Highlighted in Org. Process Res. Dev. 2017, 21, 279-291).

57. G. Fumagalli, S. Stanton and J. F. Bower*; Recent methodologies that exploit C-C single bond cleavage of strained ring systems by transition metal complexes. Chem. Rev. 2017, 117, 9404-9432. Invited contribution to the 2017 thematic issue on C-H and C-C functionalisation.

56. G.-W. Wang, N. G. McCreanor, M. H. Shaw, W. G. Whittingham and J. F. Bower*; New initiation modes for directed carbonylative C-C bond activation: rhodium-catalyzed (3+1+2) cycloadditions of aminomethylcyclopropanes. J. Am. Chem. Soc. 2016, 138, 13501-13504. (open access)

55. G. A. M. Jardim, J. F. Bower* and E. N. da Silva Júnior*; Rh-catalyzed reactions of 1,4-benzoquinones with electrophiles: C-H iodination, bromination and phenylselenation. Org. Lett. 2016, 18, 4454-4457.

publication 55

54.  N. G. McCreanor, S. Stanton and J. F. Bower*; Capture-collapse heterocyclization: 1,3-diazepanes by C-N reductive elimination from rhodacyclopentanones. J. Am. Chem. Soc. 2016, 138, 11465-11468. (open access)

publication 54

53. M. H. Shaw and J. F. Bower*; Synthesis and applications of rhodacyclopentanones derived from C-C bond activation. Chem. Commun. 2016, 52, 10817-10829 (open access review article)

Publication 53

52. I. R. Hazelden, X. Ma, T. Langer and J. F. Bower*; Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides. Angew. Chem. 2016, 128, 11364-11368; Angew. Chem. Int. Ed. 2016, 55, 11198-11202. (open access)

Publication 52

51. G. E. M. Crisenza, E. Dauncey and J. F. Bower*; C2-Alkenylation of N-heteroaromatic compounds via Brønsted acid catalysis. Org. Biomol. Chem. 2016, 14, 5820-5825. Invited contribution to the 2016 New Talent Special Issue. (open access)

Publication 51

50. A. S. Henderson, J. F. Bower* and M. C. Galan*; Carbohydrates as enantioinduction components in stereoselective catalysis. Org. Biomol. Chem. 2016, 14, 4008-4017. (open access review article)

Publication 50

49. G. A. M. Jardim, E. N. da Silva Júnior* and J. F. Bower*; Overcoming naphthoquinone deactivation: rhodium-catalyzed C-5 selective C-H iodination as a gateway to functionalized derivatives. Chem. Sci. 2016, 7, 3780-3784. (open access)Publication 49

48. G. E. M. Crisenza and J. F. Bower*; Branch selective Murai-type alkene hydroarylation reactions. Chem. Lett. 2016, 45, 2-9. (open access review article)

Publication 48


47. N. J. Race, A. Faulkner, M. H. Shaw and J. F. Bower*; Dichotomous mechanistic behavior in Narasaka-Heck cyclizations: electron rich Pd-catalysts generate iminyl radicals. Chem. Sci. 2016, 7, 1508-1513. (open access)

Publication 48

46. M. H. Shaw, W. G. Whittingham and J. F. Bower*; Directed carbonylative (3+1+2) cycloadditions of amino-substituted cyclopropanes and alkynes: reaction development and increased efficiencies using a cationic rhodium system. Tetrahedron 2016, 72, Symposium-in-print, Catalytic C–C bond formation by C–H functionalization and C–C bond cleavage, 2731-2741. (open access)

publication 44

45. G. E. M. Crisenza, O. O. Sokolova and J. F. Bower*; Branch selective alkene hydroarylation by cooperative destabilization: iridium-catalyzed ortho-alkylation of acetanilides. Angew. Chem. 2015, 127, 15079-15083; Angew. Chem. Int. Ed. 2015, 54, 14866-14870. (open access)

Publication 46

44. A. S. Henderson, S. Medina, J. F. Bower* and M. C. Galan*; Nucleophilic aromatic substitution as an approach to challenging carbohydrate-aryl ethers. Org. Lett. 2015, 17, 4846-4849. (open access)

43. M. H. Shaw, R. A. Croft, W. G. Whittingham and J. F. Bower*; Modular access to substituted azocanes via a rhodium-catalyzed cycloaddition-fragmentation strategy. J. Am. Chem. Soc. 2015, 137, 8054-8057. (open access)

publication 43

42. A. Faulkner, J. S. Scott and J. F. Bower*; An umpolung approach to alkene carboamination: palladium catalyzed 1,2-amino-acylation, -carboxylation, ‑arylation, -vinylation and -alkynylation. J. Am. Chem. Soc. 2015, 137, 7224-7230. (open access)

publication 42

41. S. Medina, A. S. Henderson, J. F. Bower and M. C. Galan*; Stereoselective synthesis of glycosides using (salen)Co catalysts as promoters. Chem. Commun. 2015, 51, 8939-8941. (open access)

40. N. J. Race and J. F. Bower*; Synthesis of heteroaromatic compounds by alkene and enyne metathesis. Top. Heterocycl. Chem. DOI: 10.1007/7081_2015_145. (review article)

39. M. H. Shaw, N. G. McCreanor, W. G. Whittingham and J. F. Bower*; Reversible C-C bond activation enables stereocontrol in Rh-catalyzed carbonylative cycloadditions of aminocyclopropanes. J. Am. Chem. Soc. 2015, 137, 463-468. (open access)

Publication 39

38. A. S. Henderson, J. F. Bower* and M. C. Galan*; Carbohydrate-based N-heterocyclic carbenes for enantioselective catalysis. Org. Biomol. Chem. 2014, 12, 9180-9183. (open access)

publication 38

37. G. E. M. Crisenza, N. G. McCreanor and J. F. Bower*; Branch selective iridium-catalyzed hydroarylation of monosubstituted alkenes via a cooperative destabilization strategy. J. Am. Chem. Soc. 2014, 136, 10258-10261. (open access)

Publication 37

36. A. Faulkner, N. J. Race, J. S. Scott and J. F. Bower*; Copper catalyzed Heck-like cyclizations of oxime esters. Chem. Sci. 2014, 5, 2416-2421. (open access)

Publication 36

35.  N. J. Race and J. F. Bower*; Palladium catalyzed cyclizations of oxime esters with 1,2-disubstituted alkenes: synthesis of dihydropyrroles. Org. Lett. 2013, 15, 4616-4619. (open access)

Publication 35

34.  M. H. Shaw, E. Y. Melikhova, D. P. Kloer, W. G. Whittingham and J. F. Bower*; Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: rhodium catalyzed multicomponent synthesis of N-heterobicyclic enones. J. Am. Chem. Soc. 2013, 135, 4992-4995. (open access)

Publication 34

33.  P. M. Murray,* J. F. Bower, D. K. Cox, E. K. Galbraith, J. S. Parker and J. B. Sweeney*; A robust first-pass protocol for the Heck-Mizoroki reaction. Org. Process Res. Dev. 2013, 17, 397-405.

32.  A. Faulkner, J. S. Scott and J. F. Bower*; Palladium catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes: synthesis of α,α-disubstituted dihydropyrroles and studies towards an asymmetric protocol. Chem. Commun. 201349, 1521-1523. (open access)

publication 32

31.  A. Faulkner and J. F. Bower*; Highly efficient Narasaka-Heck cyclizations mediated by P(3,5-(CF3)2C6H3)3: facile access to N-heterobicyclic scaffolds. Angew. Chem. 2012, 124, 1707-1711; Angew. Chem. Int. Ed. 2012, 51, 1675-1679.

Link to full-size graphical abstract

30.  T. J. Donohoe,* J. F. Bower and L. K. M. Chan; Olefin cross-metathesis for the synthesis of heteroaromatic compounds. Org. Biomol. Chem. 2012, 10, 1322-1328.

        • Highlighted as a “Hot” Emerging Area.

29.  T. J. Donohoe,* J. F. Bower, D. B. Baker, J. A. Basutto, L. K. M. Chan and P. Gallagher; Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence. Chem. Commun. 2011, 47, 10611-10613.

28.  T. J. Donohoe,* J. A. Basutto, J. F. Bower and A. Rathi; Heteroaromatic synthesis via olefin cross-metathesis: entry to polysubstituted pyridines. Org. Lett. 2011, 13, 1036-1039.

27.  J. F. Bower and M. J. Krische*; Formation of C-C bonds via iridium catalyzed hydrogenation and transfer hydrogenation. Top. Organomet. Chem. 2011, 34, 107-138.

26.  T. J. Donohoe,* J. F. Bower and J. A. Basutto; Olefin cross-metathesis based approaches to furans: procedures for the preparation of di- and trisubstituted variants. Nature Protocols 2010, 5, 2005-2010.

25.  T. J. Donohoe,* N. J. Race, J. F. Bower and C. K. A. Callens; Substituted pyrroles via olefin cross-metathesisOrg. Lett. 2010, 12, 4094-4097.

24.  T. J. Donohoe* and J. F. Bower; An expedient route to substituted furans via olefin cross-metathesis. Proc. Natl. Acad. Sci. U.S.A. 2010,107, 3373-3376.

23.  J. F. Bower,* J. Rujirawanich and T. Gallagher*; N-Heterocycle construction via cyclic sulfamidates. Applications in synthesis. Org. Biomol. Chem. 2010, 8, 1505-1519.

22.  T. J. Donohoe,* J. F. Bower, J. A. Basutto, L. P. Fishlock, P. A. Procopiou and C. K. A. Callens; Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines. Tetrahedron 2009, 65, Symposium-in-print, Modern applications of transition metal catalysis in heterocycle synthesis, 8969-8980.

21.  T. J. Donohoe,* L. P. Fishlock, J. A. Basutto, J. F. Bower, P. A. Procopiou and A. L. Thompson; Synthesis of substituted pyridines and pyridazines via ring closing metathesis. Chem. Commun. 2009, 3008-3010.

20.  J. F. Bower and M. J. Krische*; Hydrogenation for C-C bond formation. In Handbook of Green Chemistry – Green Catalysis, Volume 1: Homogeneous Catalysis. P. T. Anastas and R. H. Crabtree (Eds.), Wiley-VCH: Weinheim, 2009, 205-254.

19.  J. F. Bower, I. S. Kim, R. L. Patman and M. J. Krische*; Catalytic carbonyl addition through transfer hydrogenation: a departure from preformed organometallic reagents. Angew. Chem. 2009121, 36-48; Angew. Chem. Int. Ed. 2009, 48, 34-46.

18.  R. L. Patman, J. F. Bower, I. S. Kim and M. J. Krische*; Formation of C-C bonds via catalytic hydrogenation and transfer hydrogenation: vinylation, allylation and enolate addition of carbonyl compounds and imines. Aldrichimica Acta 2008, 41, 95-104.

17.  J. S. Parker,* J. F. Bower, P. M. Murray, B. Patel and P. Talavera; Kepner-Tregoe decision analysis as a tool to aid route selection. Part 3. Application to a back-up series of compounds in the PDK project. Org. Process Res. Dev. 2008, 12, 1060-1077.

16.  F. Shibahara, J. F. Bower and M. J. Krische*; Diene hydroacylation from the alcohol or aldehyde oxidation level via ruthenium-catalyzed C-C bond-forming transfer hydrogenation: synthesis of β,γ-unsaturated ketones. J. Am. Chem. Soc. 2008, 130, 14120-14122.        

15.  R. L. Patman, V. M. Williams, J. F. Bower and M. J. Krische*; Carbonyl propargylation from the alcohol or aldehyde oxidation level employing 1,3-enynes as surrogates to preformed allenyl metal reagents: a ruthenium catalyzed C-C bond forming transfer hydrogenation. Angew. Chem. 2008, 120, 5298-5301; Angew. Chem. Int. Ed. 2008, 47, 5220-5223.

14.  F. Shibahara, J. F. Bower and M. J. Krische*; Ruthenium catalyzed C-C bond forming transfer hydrogenation: carbonyl allylation from the alcohol or aldehyde oxidation level employing acyclic 1,3-dienes as surrogates to preformed allyl metal reagents. J. Am. Chem. Soc. 2008, 130, 6338-6339.

13.  J. F. Bower, R. L. Patman and M. J. Krische*; Iridium catalyzed C-C coupling via transfer hydrogenation: carbonyl addition from the alcohol or aldehyde oxidation level employing 1,3-cyclohexadiene. Org. Lett. 200810, 1033-1035.

        • Highlighted in SYNFACTS 2008, 505.

12.  J. F. Bower, E. Skucas, R. L. Patman and M. J. Krische*; Catalytic C-C coupling via transfer hydrogenation: reverse prenylation, crotylation and allylation from the alcohol or aldehyde oxidation level. J. Am. Chem. Soc. 2007, 129, 15134-15135.

        • Highlighted in SYNFACTS 2008, 293.

11.  E. Skucas, J. F. Bower and M. J. Krische*; Carbonyl allylation in the absence of preformed allyl metal reagents: reverse prenylation via iridium catalysed hydrogenative coupling of dimethylallene. J. Am. Chem. Soc. 2007, 129, 12678-12679.

10.  J. F. Bower, P. Szeto and T. Gallagher*; Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines. Org. Lett. 2007, 9, 4909-4912.

9.  J. F. Bower, P. Szeto and T. Gallagher*; Enantiopure 1,4-benzoxazines via 1,2-cyclic sulfamidates.  Synthesis of levofloxacin. Org. Lett. 2007, 9, 3283-3286.

8.  J. F. Bower, A. J. Williams, H. Woodward, P. Szeto, R. M. Lawrence and T. Gallagher*; Reactivity of cyclic sulfamidates towards phosphonate-stabilised enolates: synthesis and applications of α-phosphono lactams. Org. Biomol. Chem. 2007, 5, 2636-2644.

7.  J. F. Bower, T. Riis-Johannessen, P. Szeto, A. J. Whitehead and T. Gallagher*; Stereospecific construction of substituted piperidines.  Synthesis of (-)-paroxetine and (+)-laccarin. Chem. Commun. 2007,728-730.

        • Highlighted in SYNFACTS 2007, 574.

6.  J. F. Bower, P. Szeto and T. Gallagher*; Cyclic sulfamidates as versatile lactam precursors.  An evaluation of synthetic strategies towards (-)-aphanorphine. Org. Biomol. Chem. 2007, 5, 143-150.

5.  J. F. Bower, S. Chakthong, J. Švenda, A. J. Williams, R. M. Lawrence, P. Szeto and T. Gallagher*; Reactivity of cyclic sulfamidates towards sulfur-stabilised enolates. Stereocontrolled synthesis of functionalised lactams. Org. Biomol. Chem. 2006, 4, 1868-1877.

4.  J. F. Bower, P. Szeto and T. Gallagher*; Cyclic sulfamidates as lactam precursors. An efficient asymmetric synthesis of (-)-aphanorphine. Chem. Commun. 2005, 5793-5795.

3.  J. F. Bower, J. Švenda, A. J. Williams, J. P. H. Charmant, R. M. Lawrence, P. Szeto and T. Gallagher*; Cyclic sulfamidates as vehicles for the synthesis of substituted lactams. Org. Lett. 2004, 6, 4727-4730.

2.  J. F. Bower, S. A. Cotton,* J. Fawcett, R. S. Hughes and D. R. Russell; Praseodymium complexes of 2,2′-bipyridine; the crystal and molecular structures of Pr(bipy)3(NCS)3, Pr(bipy)2(NO3)3, Pr(bipy)2Cl3(OH2)·EtOH and Pr(bipy)(S2CNEt2)3. Polyhedron 2003, 22, 347-354.

1.  J. F. Bower, S. A. Cotton,* J. Fawcett* and D. R. Russell; Bis(2,2′-bipyridyl-N,N‘)tris(nitrato-O,O‘)neodymium. Acta Cryst. 2000, C56, e8-e9.

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